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BAY 80-6946 (Copanlisib CAS number 1032568-63-0) is a small molecule inhibitor targeting class I phosphatidylinositol-3-kinase (PI3K) with potent inhibitory activity against PI3K- and PI3K- isoforms By blocking PI3K enzymatic activity Copanlisib interferes with downstream signaling pathways crucial for cell proliferation and survival In vitro studies demonstrate notable antiproliferative effects in cancer cell lines such as HuCCT-1 and EGI-1 (KRASG12D mutants) exhibiting IC50 values of approximately 147 nM and 137 nM respectively Clinical trials indicate potential utility in treating B-cell malignancies like chronic lymphocytic leukemia and non-Hodgkin lymphoma
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Pyruvic acid-13C (sodium) is the 13C-labeled Pyruvic acid Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates proteins and fats
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3-Bromopyruvate is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. It inhibits cell growth and induces apoptosis by interfering with glycolysis, and induces autophagy by stimulating ROS formation in breast cancer cells. It also exhibits antimicrobial activities.
Analogue of pyruvate
Potent hexokinase (HK)-II inhibitor with high tumor selectivity
Inhibits cell growth
Induces apoptosis by interfering with glycolysis
Induces autophagy by stimulating ROS formation in breast cancer cells
Exhibits antimicrobial activities
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Pyruvic acid (Standard) is the analytical standard of Pyruvic acid This product is intended for research and analytical applications Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates proteins and fats
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3-Bromopyruvic acid (CAS 1113-59-3) abbreviated as 3-BP is a small molecule inhibitor that targets hexokinase II (HK2) an enzyme notably upregulated in cancerous cells By inhibiting HK2 activity (Ki 2 4 mM) 3-BP interferes with glycolytic energy metabolism leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells In mouse xenograft models of hepatocellular carcinoma administration of 3-BP (50 mg/kg/day six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis This compound serves as a tool in oncology research particularly for studying glycolysis-dependent tumor metabolism
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